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Neurochemical classification of serotonin-immunoreactive neurons co-innervating motor endplates in the mouse esophagus

  • Serotonin immunoreactivity was previously found in myenteric neurons co-innervating motor endplates in the mouse esophagus striated muscle and aninvolvement in motility control was suggested. However, it is not known ifother neuroactive substances are present in these neurons and to what extentthey co-localize. First, vasoactive intestinal peptide (VIP) was established as abona fide marker for putative inhibitory myenteric neurons by evaluating co-localization with neuronal nitric oxide synthase (nNOS) and neuropeptide Y(NPY). Then, co-localization of serotonin and VIP was tested in co-innervatingaxons on motor endplates, which were visualized withα-bungarotoxin (α-BT)by multilabel immunofluorescence. Myenteric ganglia were also surveyed forco-localization in neuronal perikarya and varicosities. nNOS, NPY, and VIPwere completely co-localized in enteric co-innervating nerve terminals onmotor endplates. After co-staining with VIP, we found (a) serotonin (5-HT)-positive nerve endings without VIP (44% of 5-HT-positively innervated end-plates), (b) 5-HT- and VIP-positive endings without co-localization (35%), and(c) 5-HT- and VIP-positive endings with co-localization (21%). About one-fifthof nerve terminals on motor endplates containing 5-HT originate from putativeinhibitory peptidegic nitrergic neurons. However, the majority represents a different population presumably subserving different functions.

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Verfasserangaben:Jillena Zinsser-Krys, Christopher Kapitza, Lena Böhnke, Piet van der KeylenORCiDGND, Winfried L. Neuhuber, Jürgen Wörl
URL:https://anatomypubs.onlinelibrary.wiley.com/doi/epdf/10.1002/ar.25030
DOI:https://doi.org/10.1002/ar.25030
Titel des übergeordneten Werkes (Englisch):The Anatomical Record
Dokumentart:Aufsatz
Sprache:Englisch
Jahr der Fertigstellung:2022
Datum der Freischaltung:27.04.2023
GND-Schlagwort:Neurochemie
Jahrgang:306
Ausgabe / Heft:5
Erste Seite:960
Letzte Seite:971
DDC-Sachgruppen:600 Technik, Medizin, angewandte Wissenschaften / 610 Medizin, Gesundheit
Zugriffsrecht:Frei zugänglich
Hochschulen:Evangelische Hochschule Nürnberg
Hochschulbibliographie:Evangelische Hochschule Nürnberg
Lizenz (Deutsch):License LogoCreative Commons - CC BY - Namensnennung 4.0 International